Prescribing Information | Important Safety Information
Prescribing Information | Important Safety Information

Call Orfadin4U at 1-877-473-3179 Email orfadin.us@sobi.com

What's new with Orfadin4U?

As you know, HT-1 is a life-long condition, and we're here to support you every step of the way. We're rolling out interactive presentations designed to make sure that you know what you need to know. The first presentation offers an overview of HT-1 and what it means on a day-to-day basis. When you're done going through it, take a short survey to unlock additional tools.
   

Good-to-know information:

Orfadin4U is the exclusive pharmacy services provider for the distribution of Orfadin in the U.S. You may contact an Orfadin4U specialist via:

Hours of Operation: 7:00 am – 6:00 pm CST

  • After Hours Support Available 24/7
  • Staffed by Pharmacists and Nurses

What is Orfadin4U?

Orfadin4U is a comprehensive patient support program for Orfadin patients and their caregivers. We offer educational material on HT-1, as well as guidance on:

  • Diet Plan: Help with mealtime planning
  • Treatment Plan: Answers to question about treatment
  • Lifestyle Plan: Everyday lifestyle management

When you enroll in Orfadin4U, help is always just a phone call away. Through Orfadin4U, you can take advantage of the following services:

Direct-to-You Pharmacy Service

  • Convenient at-home prescription delivery
  • Refill management to ensure reliable on-time delivery
  • Phone and email reminders to keep you informed and on track

Co-Pay Assistance and Insurance Coverage Management for Eligible Patients

  • Benefits verification and reimbursement support
  • Information on financial assistance for co-pays and deductibles
  • Help with prior authorization and coverage appeals

Educational and Nutritional Information

  • Patient education from qualified healthcare professionals
  • Dietary and nutrition information
  • Resources to help you manage HT-1

Indication and Usage

Orfadin is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase indicated for use as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1 (HT-1).

Important Safety Information

    • Tyrosine levels can increase in the blood if you do not restrict tyrosine and phenylalanine in your diet while taking Orfadin. Too much tyrosine in the blood can cause serious eye problems or other complications.
    • Do not adjust your Orfadin dosage in order to lower the tyrosine levels in the blood.
    • A reduction in the number of white cells and platelets in the blood have been observed during treatment with Orfadin. Your platelet and white blood cell counts should be monitored regularly during Orfadin treatment.
    • The most common adverse reactions to taking Orfadin are liver cancer, liver failure, low platelets or white cells in the blood, and complaints related to the eyes, including conjunctivitis, corneal opacity, inflammation of the cornea, and extreme sensitivity to light.
    • Tell your physician promptly if you have unexplained eye symptoms, rash, jaundice (yellowing of the skin or whites of the eyes) or excessive bleeding.
    • Use Orfadin during pregnancy only if the potential benefit justifies the potential risk to the fetus.
    • Nursing women should discontinue either Orfadin or breast-feeding based on the recommendation of your healthcare professional.
      Please see full Prescribing Information